Why Rabbit Monoclonal Antibodies?

Rabbit monoclonal antibody

Why should you choose rabbit monoclonal antibodies for your antibody development process? Rabbits offer a strategic advantage over mice in terms of monoclonal antibody production. The rabbit spleen contains more B cells than the mouse spleen because rabbits are larger. The more B cells, the more antibodies are produced, resulting in a greater chance of finding the ideal branch for expansion. To get the services of rabbit monoclonal antibody service browse the internet sources for details.

Image Source: Google

Antibodies to various epitopes

The rabbit immunoglobulin gene produces antibodies that respond to a much wider range of epitopes than mouse antibodies. Protein isoforms can differ by one amino acid residue, leading to slight structural aberrations. The rabbit's immune system recognizes these complex variations better by producing monoclonal antibodies. On average, rabbit monoclonal antibodies bind with 10-100-fold higher affinity than mouse monoclonal antibodies.

More small fragments are immunogenic in rabbits than in mice

The rabbit immune system is able to achieve an immunogenic response to small particles much more quickly than the mouse immune system. When a small molecule with a small epitope was injected into rabbits and mice side by side, rabbits were more likely to have high titers than mice because rabbits had more complex immune responses.

Decreased immunodominance

Immune dominance is when some epitopes of the same antigen are more immunogenic than others. As a result, the immune system produces a large number of antibodies against the dominant immunogenic epitope and few antibodies against other epitopes. Rabbits showed lower immunodominance than mice.